Prosper Mérimée, Plays on Hispanic Themes

Themes on Differential Inclusions (

An ordinary differential equation x = f (t, x(t)) (ODE) uniquely assigns the time derivative x (t) = d dt x(t) as a function of t and x. A differential inclusion x ∈ F (t, x(t)), (DI) on the other hand, only requires that the derivative x be inside a given set F (t, x) ⊂ R n. Therefore, given an initial condition x(0) = ¯ x, one can usually find several solutions of (DI). f(x) x _ x _ x x F(x) ...

Prosper Pilot Case Study

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Live long and prosper.

In this issue of Molecular Pharmacology, Meyn et al. (p. 1320) provide the results of the first comprehensive investigation of the expression pattern of the Src family of nonreceptor tyrosine kinases (SFK) in mouse embryonic stem (ES) cells. They found that self-renewing ES cells express seven of the eight mammalian SFK members and that some undergo distinct expression changes during early diff...

The PROSPER Toolkit ? Louise

Themes and variations on ubiquitylation.

Ubiquitylation--the conjugation of proteins with a small protein called ubiquitin--touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why ...